化学发光/电化学发光新体系和新材料的开发及其生物分析应用研究

2008-09至2012-06  中国科学技术大学 化学 学士

2012-09至2018-03  中国科学技术大学 分析化学 博士 导师：崔华教授

2018-03至2021-01    中国科学技术大学  博士后

2021-02至2026-01    中国科学技术大学  特聘副研究员

2026-03至今    安徽师范大学     副教授

1. 国家自然科学基金，青年科学基金项目，22204157，抗体定向组装的金属有机框架电化学发光纳米发光体及其在体外诊断中的应用研究，2023-01-01 至 2025-12-31，30万元，结题，主持。

2. 中国博士后科学基金，面上资助，2019M662154，基于单纳米粒子电化学发光成像的纳米发光体设计及应用，2019-11 至 2021-11, 8万元，结题，主持。

3. 中国科学技术大学青年创新基金，WK2060190097，基于单纳米粒子电化学发光成像的新型高效纳米发光体的设计、合成及应用，2019-01 至 2020-12, 13万元，结题，主持。

4. 国家自然科学基金，重点项目，延迟化学发光及其在智能传感中的应用，2025-01 至 2029-12，230万元，在研，参与（2/4）。

5. 国家自然科学基金，面上项目，21874122, 电位分辨的多色电化学发光纳米发光体及其分析应用研究，2019-01-01至2022-12-31，64万元，结题，参与（2/6）。

以第一作者/通讯作者发表的主要论文如下：

1. Manli Wang, Jiangnan Shu*, Gang Teng, Dongliang Yang, Tianhua Zheng* and Hua Cui*, Label-free Imaging Immunosensor Based on Nickel-manganese Double Hydroxide with Delayed Chemiluminescence Properties for Detection of CYFRA21-1, Analytical Chemistry, 2025, 97, 11202-11210.

2. Chao Hu, Jiangnan Shu*, Wei Nie, Yisha Wang and Hua Cui*, Dissolved Oxygen-Induced Highly Efficient Chemiluminescence of Acridinium Sulfonamide-Functionalized MnFe₂O₄ Nanoparticles for Sensitive Detection of Ascorbic Acid, Sensors and Actuators B: Chemical, 2025, 431, 137399.

3. Wencan Zhang, Jiangnan Shu*, Manli Wang, Keying Zheng and Hua Cui*, One-Pot Synthesis of N-(4-Aminobutyl)-N-ethylisoluminol Doping Cuprous Oxide Nanocubes for Label-Free Chemiluminescence Immunoassay of Cardiac Troponin I, Analytical Chemistry, 2025, 97, 12116−12124.

4. Manli Wang, Jiangnan Shu*, Yisha Wang, Wencan Zhang, Keying Zheng, Shengnian Zhou, Dongliang Yang* and Hua Cui*, Ultrasensitive PD-L1-expressing Exosome Immunosensors Based on a Chemiluminescent Nickel-Cobalt Hydroxide Nanoflower for Diagnosis and Classification of Lung Adenocarcinoma, ACS Sensor, 2024, 9, 3444-3454.

5. Manli Wang, Jiangnan Shu*, Ruoxian Zhang, Dongliang Yang, Gang Teng,* and Hua Cui*, Chemiluminescent Fe₃O₄@nickel-cobalt Double Hydroxide Magnetic Core-Shell Nanomaterial as an Analytical Interface for Label-Free CYFRA21‑1 Immunosensing, Analytical Chemistry, 2024, 96, 18890-18897.

6. Chao Hu, Jue Wang, Yisha Wang, Mohammad A. Haghighatbin, Jiangnan Shu* and Hua Cui*, Chemiluminescent Poly(sodium 4‑styrenesulfonate)-Encapsulated Acridinium Sulfonamide-Functionalized CoFe₂O₄ Nanoparticles for Detection of Cholesterol, ACS Applied Nano Materials, 2024, 7, 4537-4545.

7. Shanshan Wang, Fajin Qu, Ruoxian Zhang, Tengchuan Jin, Tianhua Zheng, Jiangnan Shu* and Hua Cui*, Emission Onset Time-Adjustable Chemiluminescent Gold Nanoparticles with Ultrastrong Emission for Smartphone-Based Immunoassay of Severe Acute Respiratory Syndrome Coronavirus 2 Antigen, Analytical Chemistry, 2023, 95, 12497-12504.

8. Manli Wang, Jiangnan Shu*, Shanshan Wang, Aihua Lyu, Yisha Wang, Dabing Huang, and Hua Cui*, N-(4-aminobutyl)-N-ethylisopropanol and Co²⁺ Dual-Functionalized Core-Shell Fe₃O₄@Au/Ag Magnetic Nanomaterials with Strong and Stable Chemiluminescence for Label-Free Exosome Immunosensor, Analytical Chemistry, 2023, 95, 12982-12991.

9. Mingquan Guo, Jiangnan Shu*, Dexin Du, Yisha Wang and Hua Cui*, Tetrakis (4-carboxyphenyl) porphyrin and Ru(bpy)₃²⁺ modified SiO₂ nanospheres for potential and wavelength resolved electrochemiluminescence, Journal of Materials Chemistry C, 2023, 11, 13106-13112.

10. Tianhua Zheng, Wei Nie, Lu Yu, Jiangnan Shu, Yaohua Li, Changlin Tian, Wei Wang, Hua Cui*, A Chemical Timer Approach to Delayed Chemiluminescence, PANS, 2022, 119(43): e2207693119.

11. Yisha Wang, Jiangnan Shu*, Aihua Lyu, Manli Wang, Chao Hu, and Hua Cui*, Zn²⁺-Modified Nonmetal Porphyrin-Based Metal–Organic Frameworks with Improved Electrochemiluminescence for Nanoscale Exosome Detection, ACS Applied Nano Materials, 2023, 6(6), 4214-4223.

12. Fajin Qu, Jiangnan Shu*, Shanshan Wang, Mohammad A. Haghighatbin, and Hua Cui*, Chemiluminescent Nanogels as Intensive and Stable Signal Probes for Fast Immunoassay of SARS-CoV‑2 Nucleocapsid Protein, Analytical Chemistry, 2022, 94, 17073-17080.

13. Mingquan Guo¹, Jiangnan Shu^1, *, Dexin Du, Mohammad A. Haghighatbin, DiYang, Zhiping Bian and Hua Cui*, A Label-Free Three Potential Ratiometric Electrochemiluminescence Immunosensor for Cardiac Troponin I Based on N-(4-aminobutyl)-N-ethylisoluminol Functionalized Graphene Quantum Dots, Sensors and Actuators B: Chemical, 2021, 334, 129628.

14. Dexin Du, Jiangnan Shu*, Mingquan Guo, Mohammad A. Haghighatbin, Di Yang, Zhiping Bian and Hua Cui*, Potential-Resolved Differential Electrochemiluminescence Immunosensor for Cardiac Troponin I Based on MOF-5-Wrapped CdS Quantum Dot Nanoluminophores, Analytical Chemistry, 2020, 92, 20, 14113-14121.

15. Zhili Han¹, Jiangnan Shu¹, Xu Liang and Hua Cui*, Label-Free Ratiometric Electrochemiluminescence Aptasensor Based on Nanographene Oxide Wrapped Titanium Dioxide Nanoparticles with Potential-Resolved Electrochemiluminescence, Analytical Chemistry, 2019, 91, 19, 12260-12267.

16. Jiangnan Shu, Zhili Han and Hua Cui*, Highly chemiluminescent TiO₂/tetra(4-carboxyphenyl)porphyrin/N-(4-aminobutyl)-N-ethylisoluminol nanoluminophores for detection of heart disease biomarker copeptin based on chemiluminescence resonance energy transfer", Analytical and Bioanalytical Chemistry, 2019, 1618-2650.

17. Jiangnan Shu, Zhili Han, Tianhua Zheng, Dexin Du, Guizheng Zou and Hua Cui*, Potential-Resolved Multicolor Electrochemiluminescence of N-(4-Aminobutyl)-N-ethylisoluminol/tetra(4-carboxyphenyl)porphyrin/TiO₂ Nanoluminophores. Analytical Chemistry, 2017, 89, 23, 12636-12640.

18. Yating Liu, Wen Shen, Qi Li, Jiangnan Shu, Lingfeng Gao, Mingming Ma, Wei Wang and Hua Cui*, Firefly-Mimicking Intensive and Long-Lasting Chemiluminescence Hydrogels, Nature Communications, 2017, 8, 1003.

19. Jiangnan Shu, Wei Wang, and Hua Cui. Direct Electrochemiluminescence of Gold Nanoparticles Bifunctionalized by Luminol Analogue-Metal Complexes in Neutral and Alkaline Media. Chemical Communication, 2015, 51, 11366-11369.

20. Jiangnan Shu, Wen Shen and Hua Cui*. Ultrasensitive Label-Free Electrochemiluminescence Immunosensor Based on N-(4-aminobutyl)-N-ethylisoluminol-Functionalized Graphene Composite. Science China-Chemistry, 2015, 58, 425-432.

1.   安徽省科学技术一等奖，2021，排名：4/4。

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