研究方向
有机硅化学，稀土单原子催化，电化学合成
教育背景
2015.09—2019.06 清华大学 博士（生物学） 导师：何 伟 教授
2007.09—2011.06 山东大学 学士（化学） 导师：鲁在君 教授
工作履历
2023.03— 安徽师范大学
2019.08—2022.10 博士后 日本理化学研究所（导师：侯召民 教授）
2012.09—2015.08 研究助理 清华大学医学院 （导师：何 伟 教授）
个人荣誉
2024年安徽省海外引才计划青年项目
学术成果
1. Liu, L.; ‡ Chen, X.; ‡ Guan, G.; ‡ Su, X.; Liu, M.; Hu, Y.; He, W.; Zhang, L.;* Ma, W.;* An, K.* Rhodium-catalyzed enantioselective intermolecular C–H silylation of simple arenes: synergistic substituent effects overcome silane redistribution to enable synthesis of Si-stereogenic arylsilanes. Chem. Sci., 2026, accepted (共同通讯)
2. Zhou, X.; Chen, X.; Wei, Y.; Fan, M.; Su, X.; Li, Z.; Hu, Y.; He, W.; An, K.;* Mao, J.* CO2-controlled chemoselective 1,4-hydroxyfunctionalization of silacyclobutanes for the modular access of bioactive silanols. Sci. China Chem., 2026, doi.org/10.1007/s11426-025-3375-x (共同通讯)
3. Chen, X.; Zhao, S.; Zhu, C.; Chen, Q.; Yu, D.; Wang, C.; Hu, Y.; An, K.;* Mao, J.* Selective Oxidation of Tertiary Silanes Enabled by Tandem Single Atom Cerium Catalyzed Water Splitting/Non-Bonding Phosphorus Site Promoted Nucleophilic Substitution. Angew. Chem. Int. Ed. 2026, 65, e9701815. (共同通讯)
4. An, K.; Liu, M.; Wang, J.; Nishiura, M.; Cong, X.;* Hou, Z.* Synthesis of [1,3]-thiasilolanes via rare-earth-catalysed intramolecular α-C(sp3)–H silylation of alkyl sulphides with hydrosilanes. Chem. Commun. 2025, 61, 17181–17184. (第一作者)
5. Yang, J.-Y.; Du, Y.-R.; Cheng, F.-Q.; An, K.; Hu, Y.;* Li, Z.-Y.* Construction of Axially Chiral Dialdehydes via Rhodium-Catalyzed Enantioselective C−H Amidation. Angew. Chem. Int. Ed. 2025, 64, e202421412.
6. Lou, S.; ‡ Wang, P.; ‡ Wen, X.; ‡ Mishra, A.; ‡ Cong, X.; Zhuo, Q.; An, K.; Nishiura, M.; Luo, Y.;* Hou, Z.* (Z)-Selective Isomerization of 1,1-Disubstituted Alkenes by Scandium-Catalyzed Allylic C–H Activation. J. Am. Chem. Soc., 2024, 146, 26766–26776.
7. Cong, X.; Hao, N.; Mishra, A.; Zhuo, Q.; An, K.; Nishiura, M.; Hou, Z.* Regio- and Diastereoselective Annulation of α, β-Unsaturated Aldimines with Alkenes via Allylic C(sp3)–H Activation by Rare-Earth Catalysts. J. Am. Chem. Soc. 2024, 146, 10187–10198.
8. Lin, X. ‡; An, K. ‡; Zhuo, Q.; Nishiura, M.; Cong, X.;* Hou, Z.* Diastereo- and Enantioselective Hydrophosphination of Cyclopropenes under Lanthanocene Catalysis. Angew. Chem. Int. Ed. 2023, 62, e202308488. (共同一作)
Before AHNU
9. Xu, W.; Cong, X.;* An, K.; Lou, S.-J.; Li, Z.; Nishiura, M.; Murahashi, T.; Hou, Z.* Regio- and Diastereoselective Formal [2+2] Cycloaddition of Allenes with Amino-Functionalized Alkenes by Rare-Earth-Catalyzed C(sp2)−H Activation. Angew. Chem. Int. Ed. 2022, 61, e202210624.
10. An, K.; He, W.* Rhodium-Catalyzed Enantioselective Intramolecular Hydrosilylation to Access Silicon-Stereogenic Tertiary Hydrosilanes. Chin. J. Org. Chem. 2022, 42, 918–920. (第一作者)
11. An, K.;‡ Ma, W.;‡ Liu, L. C.; He, T.; Guan, G.; Zhang, Q. W.;* He, W.* Rhodium Hydride Enabled Enantioselective Intermolecular C–H Silylation to Access Acyclic Stereogenic Si–H. Nat. Commun. 2022, 13, 847. (共同一作)
12. Lou, S.-J.; Luo, G.;* Yamaguchi, S.; An, K.; Nishiura, M.; Hou, Z.* Modular Access to Spiro-dihydroquinolines via Scandium-Catalyzed Dearomative Annulation of Quinolines with Alkynes. J. Am. Chem. Soc. 2021, 143, 20462–20471.
13. Zhang, L.;‡ An, K.;‡ Wang, Y.;‡ Wu, Y.-D.; Zhang, X.;* Yu, Z.-X.;* He, W.* A Combined Computational and Experimental Study of Rh-Catalyzed C–H Silylation with Silacyclobutanes: Insights Leading to a More Efficient Catalyst System. J. Am. Chem. Soc. 2021, 143, 3571–3582. (共同一作)
14. Ma, W.; Liu, L. C.; An, K.; He, T.; He, W.* Rh-Catalyzed Syntheses of Chiral Monohydrosilanes via Intramolecular C-H Functionalization of Dihydrosilanes. Angew. Chem., Int. Ed. 2021, 60, 4245–4251.
15. Yang, C.; Wang, J.; Li, J.; Ma, W.; An, K.; He, W.; Jiang, C.* Visible-Light Induced Radical Silylation for the Synthesis of Dibenzosiloles via Dehydrogenative Cyclization. Adv. Synth. Catal. 2018, 360, 3049–3054.
16. Zhang, Q. W.;‡ An, K.;‡ Liu, L. C.; Zhang, Q.; Guo, H.; He, W.* Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation. Angew. Chem., Int. Ed. 2017, 56, 1125–1129. (共同一作)
17. Zhang, Q. W.;‡ An, K.;‡ Liu, L. C.; Guo, S.; Jiang, C.; Guo, H.; He, W.* Rhodium-Catalyzed Intramolecular C-H Silylation by Silacyclobutanes. Angew. Chem., Int. Ed. 2016, 55, 6319–6323. (共同一作)
18. Zhang, Q. W.; An, K.; Liu, L. C.; Yue, Y.; He, W.* Rhodium-Catalyzed Enantioselective Intramolecular C–H Silylation for the Syntheses of Planar-Chiral Metallocene Siloles. Angew. Chem., Int. Ed. 2015, 54, 6918–6921.
19. Zhang, Q. W.; An, K.; He, W.* Catalytic Synthesis of π-Conjugated Silole through Si–C(sp3) Bond Activation. Synlett 2015, 26, 1145–1152.
20. Zhang, Q. W.; An, K.; He, W.* Rhodium-Catalyzed Tandem Cyclization/Si-C Activation Reaction for the Synthesis of Siloles. Angew. Chem., Int. Ed. 2014, 53, 5667–5671.