科研项目
1. 金属导向有机合成及其应用创新团队，安徽省高等学校科研计划项目(2022AH010011)，200万，2023-2025，主持
1. Visible-light-mediated selective α-polyfluoroarylation and alkenylation of phenol- and thiophenol-derived aryl alkyl ethers. Ting Zhang, Siyuan Xiong, Delin Wu, Tianbao Liu, Shuguang Chen*, Yongjia Shang*, Hao Wu*. Org. Chem. Front. doi.org/10.1039/d6qo01031h
2. Rhodium(III)-Catalyzed [3 + 2] Annulation of Diazo Compounds with Enaminones for Constructing Polysubstituted NH-Pyrroles. Wangcheng Hu, Miaomiao Chen, Xinyu Tong, Qiang Tang, Yongjia Shang*, Xinwei He*. Org. Lett. 2026, 28, 9343–9348.
3. Concise Synthesis of Pyrano/Benzopyrano[2,3‑c]pyrazol-6-ones via Ir/Rh-Catalyzed C–H Activation and Tandem Annulation. Miaomiao Chen, Wangcheng Hu, Wenran Ni, Zhiting Wang, Shuguang Chen*, Yongjia Shang*. J. Org. Chem., 2026, 91, 9822–9829.
4. Divergent Three-Component Assembly of Densely Functionalized Dibenzofurans via ZnCl2‑Mediated Cascade Annulation. Yanan Liu, Qiang Tang, Pui Ying Choy, Yangzilin Kong, Ni Gu, Susuo Lu, Yongjia Shang*, Fuk Yee Kwong*, Xinwei He*. Org. Lett. 2026, 28, 8859–8865.
5. Visible-light-mediated propargylation of phenols/thiophenols via organic photocatalysis. Ting Zhang, Delin Wu, Tianbao Liu, Kaiyuan Zhou, Shuguang Chen*, Yongjia Shang*, Hao Wu*. Chem. Commun. 2026, 62, 11905–11908.
6. Atroposelective Access to π‐Conjugated 1,2‐Azaborepines Enabled by Palladium‐Catalyzed Cyclization of N ‐Heterobiaryls with Alkynylboronates. Fengya He, Zhen Wang, Haoyu Guo, Shuguang Chen*, Xu Zhang, Yongjia Shang*, Hui Wang*. Adv. Sci. 2026, 13, e75755.
7. Synthesis of Visible-Light-Mediated Cyclopropanes and Cyclic Sultines by Deacylative Radical Addition–Polar Cyclization Cascade from Unstrained Ketones. Hao Wu, Shuguang Chen*, Hui Wang*, Yongjia Shang*. J. Org. Chem., 2025, 90, 17768–17775.
8. Modular Synthesis of 3,4‐Disubstituted Pyrroles Through Three‐Component Van Leusen Reaction of Propargylamines with Tosylmethyl Isocyanide and Water. Binbin Fei, Yangzilin Kong, Yanan Liu, Ni Gu, Qiang Tang, Yongjia Shang*, Xinwei He*. Eur. J. Org. Chem., 2025, 28, e202500855.
9. Direct Access to Aminocyclopentenones through Rh-catalyzed Cascade Wolff Rearrangement and Decarbonylative Amination. Lvlv Gao, Jianwei Wu, Jian Wang, Enshen Zhang,* Yongjia Shang, and Xinwei He.* Adv. Synth. Catal., 2025, 367, e70110.
10. Construction of dibenzo[1,4]oxazocines via palladium-catalysed arylalkylation of allenamides. Yue Pu, Qiaoli Xue, Liqin Yan, Xiaotian Xie, Haixia Zhao, Kaijie Tang, Yongjia Shang*, Jian Wang*. Chem. Commun, 2025, 61, 14645–14648.
11. A Palladium-Catalyzed Cascade Double Annulation Strategy for Modular Access to Dihydrocyclopenta[b]chromenes. Yanan Liu, Pui Ying Choy, Qiang Tang, Mengdi Wu, Yangzilin Kong, Yongjia Shang*, Fuk Yee Kwong*, Xinwei He*. Org. Lett. 2025, 27, 8405–8410.
12. Construction of Eight-Membered N‑Heterocycles via Palladium-Catalyzed Cyclization of Allenyl Isocyanides. Haixia Zhao, Yuchen Jiang, Jingxuan Zhang, Yue Pu, Suyun Zeng, Bohan Ni, Yongjia Shang*, Jian Wang*. Org. Lett. 2025, 27, 8005–8010.
13. Deoxygenative Cyclopropanation of Aldehydes with Acyl‐Stabilized Sulfur Ylides. Xunlan Ling, Quansheng Zhao, Xinyu Liu, Yan Wang, Yin Su, Feihu Yang, Zhihan Zhang*, Hui Wang*, Yongjia Shang*, Liang Fu*. Chem. Eur. J. 2025, 31, e202500471.
14. DBU-catalyzed annulation strategy for modular assembly of 2,3-difunctionalized dihydrobenzofurans. LiLi Yuan, Jie Wang, Qiang Tang, Yiping Wang, Beibei Ma, Yongjia Shang,* Xinwei He.* Org. Biomol. Chem., 2025, 23, 1832–1836.
15. NaHCO3-promoted Formal [4+3] Annulation of Salicylaldehydes with Isoquinolinium Salts Accessing Isoquinoline-fused Benzo[f][1,3]oxazepines. Qiang Tang,* Yannan Liu, Mengdi Wu, Yangzilin Kong, Xiaochun Jiang, Shizhang Ling,* Yongjia Shang,* Xinwei He.* Adv. Synth. Catal., 2025, 367, e202401295.
16. Efficient accessibility of indole and pyrrole nuclei via late-stage aryl C–H activation of drug molecules promoted by thianthrenium saltsnantioselective Construction of 1H-Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C−H Bond Imidoylation. Wangcheng Hu,‡ Tingting Yang,‡ Shuguang Chen,* Lili Yuan* and Yongjia Shang*. Chem. Commun., 2024, 60, 12916-12919.
17. Base-Mediated Cascade Lactonization/1,3-Dipolar CycloadditionPathway for the One-Pot Assembly of Coumarin-Functionalized Pyrrolo[2,1‑a]isoquinolines. Qiang Tang, Yanan Liu, Binbin Fei, Qianqian Tao, Chen Wang, Xiaochun Jiang,* Xinwei He,* Yongjia Shang.* J. Org. Chem., 2024, 89, 8420-8434.
18. Yinsong Wu, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Yongjia Shang,* Xinwei He.* Modular Assembly of Pyrrolo[3,4-c]isoquinolines through Rh-Catalyzed Cascade C-H Activation/Annulation of O-Methyl Aryloximes with Maleimides. J. Org. Chem., 2024, 89, 8447-8457.
19. A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines.Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu,* Yongjia Shang,* Xinwei He.* Org. Biomol. Chem., 2024, 22, 3523-3532.
20. Palladium-catalysed aryl/monofluoroalkylation of allenamides: access to fluoroalkyl indoles and isoquinolones. Qiaoli Xue, Yue Pu, Haixia Zhao, Xiaotian Xie, Heng Zhang, Jian Wang*, Liqin Yan*, Yongjia Shang*. Chem. Commun, 2024, 60, 3794–3797.
21. Three-Component Synthesis of Multiple Functionalized Allenes via Copper/Photoredox Dual Catalyzed 1,4-Alkylcyanation of 1,3-Enynes. Yue Pu, Shumin Ding, Haixia Zhao, Qiaoli Xue, Heng Zhang, Xiaotian Xie, Yongjia Shang, Jian Wang*. Org. Lett, 2024, 26, 1834–1839.
22. Construction of C-S and C-Se Bonds from Unstrained Ketone Precursors under Photoredox Catalysis. Hao Wu, Shuguang Chen,* Chunni Liu, Quansheng Zhao, Zhen Wang, Qiren Jin, Shijie Sun, Jing Guo, Xinwei He, Patrick J Walsh,* and Yongjia Shang.* Angew. Chem. Int. Ed., 2024, 63(8), e202314790.
23. Cascade Annulation Strategy for Expeditious Assembly of Hydroxybenzo[c]chromen-6-ones and Their Photophysical Property Studies. Yanan Liu, Pui Ying Choy, Demao Wang, Mengdi Wu, Qiang Tang, Xinwei He,* Yongjia Shang,* Fuk Yee Kwong.* J. Org. Chem., 2023, 88, 16609-16620.
24. Synthesis of arene-functionalized fused heterocyclic scaffolds via a regioselective cascade 1,4-conjugate addition/5-exo-dig annulation strategy. Xinwei He,* Demao Wang, Yanan Liu, Mengdi Wu, Yangzilin Kong, Qiang Tang, Yiping Wang, Chenli Fan, Yongjia Shang.* Org. Biomol. Chem., 2023, 21, 9159–9172.
25. Base-promoted tandem synthesis of 2-azaaryl indoline. Shuguang Chen, Jiahong Tan, Hao Wu, Quansheng Zhao, Yongjia Shang*. Org. Biomol. Chem. 2023, 21, 9133–9137.
26. Access to tetrahydrophenanthridine N-oxides via Rh(III)-catalyzed cascade C-H activation/cyclization of cyclic 2-diazo-1,3-diones and aryloximes. Yinyin Feng, Guanghao Shi, Liwei Xiang, Wangcheng Hu, Xinwei He,* Yongjia Shang.* Tetrahedron, 2023, 144, 133584.
27. Visible-Light-Mediated Deacylated Alkynylation of Unstrained Ketone. Hao Wu, Shuguang Chen,* Dengmengfei Xiao, Feng Li, Kaiyuan Zhou, Xiaocui Yin, Chunni Liu, Xinwei He, Yongjia Shang.* Org. Lett., 2023, 25, 1166-1171.
28. Stereoselective Three-Component Construction of Conjugated 1,3-Dienes via Palladium-Catalyzed Alkene/Allene/Carbenoid Insertion Cascade. Haixia Zhao, Yuchen Jiang, Tongqing Weng, Yongjia Shang*, Jian Wang*. Adv. Synth. & Catal. 2023, 365, 463.
29. Rh-catalyzed Cascade C-H Activation/Annulation of N-Hydroxybenzamides and Propargylic Acetates for Modular Access to Isoquinolones. Taibei Fang, Shiwen Zhang, Qingqing Ye,* Shuwen Kong, Tingting Yang, Kaijie Tang, Xinwei He,* and Yongjia Shang.* Molecules, 2022, 27, 8553.
30. An expeditious FeCl3-catalyzed cascade 1,4-conjugate addition/annulation/1,5-H shift sequence for modular access of all-pyrano-moiety-substituted chromenes. Xinwei He,* Ruxue Li, Pui Ying Choy, Jiahui Duan, Zhenzhen Yin, Keke Xu, Qiang Tang, Rong-Lin Zhong, Yongjia Shang* and Fuk Yee Kwong. Chem. Sci., 2022, 13, 13617-13622.
31. Radical-Induced Cascade Annulation/Hydrocarbonylation for Construction of 2-Aryl-4H-chromen-4-ones. Xinwei He,* Keke Xu, Yanan Liu, Demao Wang, Qiang Tang, Wenjie Hui, Haoyu Chen, and Yongjia Shang*. Molecules, 2022, 27, 7412.
32. Metal-Free Cascade 1,4-Conjugate Addition/Selective Annulation Strategy for Divergent Synthesis of Polysubstituted Imidazoles and 4-Alkenylquinazolines. Qiang Tang, Keke Xu, Xinwei He,* and Yongjia Shang.* Adv. Synth. Catal., 2022, 364, 4103-4109.
33. Rhodium(III)-Catalyzed Three-Component Cascade Annulation for Modular Assembly of N-Alkoxylated 3-Arylisoindolin-1-ones with Tetrasubstituted Carbon Center. Wenbo Hu, Liqin Yan, Youpeng Zuo, Shuwen Kong, Yue Pu, Qiang Tang, Xinyu Wang, Xinwei He,* Yongjia Shang.* Adv. Synth. Catal., 2022, 364, 2589-2595.
34. Assembly of Pyran-Fused Isoquinolines via Rhodium-Catalyzed Double Annulations of Methyl Benzimidates with Diazo Compounds. Yinsong Wu, Enshen Zhang, Jiahui Duan, Keke Xu, Xinwei He,* Yongjia Shang.* Synthesis, 2022, 54, 4583-4591.
35. Catalytic Ring Expansion of Indole toward Dibenzoazepine Analogues Enabled by Cationic Palladium(II) Complexes, Jiaping Wu,* Yanfei Liu, Baiyang Qian, Haitao Yang, Lili Lu, Jitan Zhang,* Yongjia Shang*, ACS Catal. 2022, 12, 6216−6226.
36. Palladium-catalyzed enantioselective (2-naphthyl) methylation of azaarylmethyl amines. Shuguang Chen, Jiahong Tan, Dan Xiong, Yongjia Shang*, Jianyou Mao* and Patrick J. Walsh*. Org. Chem. Front., 2022, 9, 2721–2727.
37. Palladium-catalyzed dearomative 1,4-arylmethylenation of naphthalenes. Enshen Zhang, Chen Chen, Xueling Wang, Jian Wang,* and Yongjia Shang.* Org. Chem. Front. 2022, 9, 2600.
38. Silver-promoted dearomative [3+4] cycloaddition of anthranils with α-isocyanoacetates: access to benzodiazepines. Rui Shao,# Haixia Zhao,# Shumin Ding, Lianjie Li, Chen Chen, Jian Wang* and Yongjia Shang.* Chem. Commun, 2022, 58, 4771-4774.
39. Metal-free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines. Qiang Tang, Meng Yuan, Jiahui Duan, Keke Xu, Ruxue Li, Mengqing Xie, Shuwen Kong, Xinwei He,* Yongjia Shang.* Eur. J. Org. Chem., 2022, e202101285.
40. Palladium-catalysed alkenyl and carbonylative C-C bond activation of cyclobutanones. Chen Chen, Haixia Zhao, Yue Pu, Lulu Tang, Jian Wang* and Yongjia Shang.* Chem. Commun, 2021, 57, 12944-12947.
41. Enantioselective Construction of 1H-Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C−H Bond Imidoylation. Jian Wang,* Lianjie Li, Minxue Chai, Shumin Ding, Jing Li, Yongjia Shang,* Haixia Zhao, Dan Li, and Qiang Zhu.* ACS Catal. 2021, 11, 12367–12374.
42. Cascade Lactonization/Benzannulation of Propargylamines with Dimethyl 3-Oxoglutarate for Modular Assembly of Hydroxylated/Arene-Functionalized Benzo[c]chromen-6-ones. Jiahui Duan, Xinwei He,* Pui Ying Choy, Qi Wang, Mengqing Xie, Ruxue Li, Keke Xu, Yongjia Shang,* Fuk Yee, Kwong.* Org. Lett., 2021, 23, 6455-6460.
43. Rh(III)-Catalyzed Cascade Nucleophilic Addition/Annulation of 2‑Diazo-1,3-diketones with 1,3-Dicarbonyl Compounds To Access 6,7-Dihydrobenzofuran-4(5H)-ones. Yinsong Wu, Xinwei He,* Mengqing Xie, Ruxue Li, Yi Ning, Jiahui Duan, Enshen Zhang, Yongjia Shang.* J. Org. Chem., 2021, 86, 7370-7380.
44. Access to C2 C-H olefination, alkylation and deuteration of indoles by rhodium(III) catalysis: An entry for diverse synthesis, Jiaping Wu,* Baiyang Qian, Haitao Yang, Lili Lu, Yongjia Shang,* Jitan Zhang, Org. Chem. Front. 2021, 8, 3032–3040.
45. A Cascade Double 1,4-Addition/Intramolecular Annulation Strategy for Expditious Assembly of Unsymmetrical Dibenzofurans. Xinwei He,* Ruxue Li, Pui Ying Choy, Mengqing Xie, Jiahui Duan, Qiang Tang, Yongjia Shang,* Fuk Yee, Kwong.* Commun. Chem., 2021, 4, 42.
46. Copper-Catalyzed Cascade 1,4-Addition/Annulation/Hydrolysis of Propargylamines with 2‑Hydroxynaphthalene-1,4-diones: Direct Formation of 12-Phenacyl-11H‑benzo[b]xanthenes. Li-Qin Yan, Zhenzhen Yin, Xinwei He,* Qianqian Li, Ruxue Li, Jiahui Duan, Keke Xu, Qiang Tang, and Yongjia Shang.* J. Org. Chem., 2021, 86, 4182-4192.
47. Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines. Shuguang Chen, Langxuan Yang, Yongjia Shang, Jianyou Mao*, Patrick J. Walsh*. Org. Lett. 2021, 23, 1594–1599.
